Home Pipeline

Pipeline

We’re advancing a pipeline of siRNA therapies across a broad range of indications.

Home Pipeline

Pipeline

We’re advancing a pipeline of siRNA therapies across a broad range of indications.

Therapy Areas

Our pipeline of siRNA therapies includes a broad range of indications, such as cardiovascular, metabolic disorders, hematological, CNS, hepatitis and more. In addition to our multiple clinical assets in development, we’re pursuing new innovations through our discovery programs.

Cardiovascular disease

Product Indications Discovery IND enabling Phase I Phase II Phase III Partner
  • BW-01
  • Cardiovascular disease
  • BW-02
  • Cardiovascular disease
  • ex-China license

  • BW-05
  • Cardiovascular disease
  • global license

  • BW-07
  • Cardiovascular disease
  • BW-15
  • Cardiovascular disease
  • BW-23
  • Cardiovascular disease
  • BW-24
  • Cardiovascular disease
  • BW-32
  • Cardiovascular disease
  • BW-34
  • Cardiovascular disease

Rare disease

Product Indications Discovery IND enabling Phase I Phase II Phase III Partner
  • PKK
  • HAE
  • CFB
  • Complement mediated disease
  • C3
  • Complement mediated disease
  • C5
  • Complement mediated disease
  • MASP-2
  • Complement mediated disease
  • TTR
  • ATTR-CM, ATTR-PN, Stargardt Disease
  • TMPRSS6
  • Hematology disorders
  • BW-40
  • Hemophilia
  • BW-41
  • Genetic rare disease

Viral infection

Product Indications Discovery IND enabling Phase I Phase II Phase III Partner
  • HBV
  • Hepatitis B

Metabolic disease

Product Indications Discovery IND enabling Phase I Phase II Phase III Partner
  • INHBE
  • Obesity, Metabolic syndrome
  • PNPLA3
  • MASH
  • HSD17B13
  • MASH
  • CIDEB
  • MASH

CNS

Product Indications Discovery IND enabling Phase I Phase II Phase III Partner
  • HTT
  • Huntington's disease
  • MAPT
  • Alzheimer's disease
  • APP
  • Alzheimer's disease
  • ApoE
  • Alzheimer's disease
  • SNCA
  • Parkinson's disease
  • LRRK2
  • Parkinson's disease
  • NAV1.7
  • Pain
  • NAV1.8
  • Pain
  • BWS-25
  • Genetic rare disease

Heart

Product Indications Discovery IND enabling Phase I Phase II Phase III Partner
  • BWH-01
  • Heart disease
  • BWH-02
  • Heart disease
  • BWH-03
  • Heart disease

Muscle

Product Indications Discovery IND enabling Phase I Phase II Phase III Partner
  • BWM-02
  • Genetic rare disease
  • BWM-03
  • Genetic rare disease

Adipose

Product Indications Discovery IND enabling Phase I Phase II Phase III Partner
  • ALK7
  • Obesity
  • BWA-02
  • Obesity
  • BWA-03
  • Obesity

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