Oligo Synthesis AD / Sr. Manager
Shanghai R&D1.Oversee the overall management of the oligonucleotide solid-phase synthesis team and execute departmental management duties.
2.In accordance with company and departmental system management requirements, lead the systematic management of the solid-phase synthesis team and ensure the implementation of system-based management standards.
3.Serve as the primary liaison with pipeline project leads, translating their requirements into actionable tasks for the solid-phase synthesis team.
4.Ensure that all compound synthesis tasks assigned to the solid-phase synthesis team are completed on time and to high quality standards.
5.Manage all resources within the solid-phase synthesis team, promptly identifying and communicating any resource allocation issues or needs.
6.Oversee quality management for the solid-phase synthesis team's output, including the quality of delivered compound materials and the accuracy/quality of documentation, reports, and records.
7.Lead developmental and process-improvement initiatives within the solid-phase synthesis team.
8.Be responsible for task assignment, capability training, performance review, and feedback for chemists within the solid-phase synthesis team.
9.Complete other tasks assigned by supervisors.
1.Master's degree or above, with at least 3 years of direct team management experience in chemical synthesis of small nucleic acids.
2.Or, Master's degree or above, with at least 6 years of experience in managing a chemical synthesis team.
3.Strong proficiency in Excel document processing.
4.Excellent timeline management and quality awareness, along with strong English communication skills.
5.Outstanding project reporting and management capabilities.
Senior Biology Scientist（In Vitro）
Shanghai R&D1.Assist the head of the in vitro/in vivo screening platform in managing partial in vitro/in vivo screening for siRNA pipeline projects, including NHP studies. Coordinate internal resources based on project priorities and ensure that screening tasks are completed on time and with high quality according to the timeline set by the project lead.
2.Collaborate closely with the project lead to translate project objectives into specific experimental plans, ensuring that experimental data are accurate, reliable, and delivered on schedule.
3.Engage in cross-departmental collaboration to track the synthesis, purification, and delivery progress of project-related compounds, ensuring seamless integration with screening workflows.
4.Provide timely and accurate in vitro/in vivo experimental data to support patent applications.
5.CRO management: Assist the platform head in technical evaluations of contract research organizations (CROs). Participate in managing certain in vivo studies conducted at CROs, track experimental progress, and review data quality and deliverables.
6.Support project advancement: Collect relevant information for assigned projects, and work with company management to define overall project objectives, milestone goals, team composition, and required internal/external resources. Develop detailed, actionable work plans, including timelines for achieving milestones. Communicate specific tasks and timelines to project team members to ensure full understanding of priorities and responsibilities. Coordinate cross-functional efforts within the project team, track implementation progress, organize key data in a timely manner, and adjust plans as needed based on results. Report progress and recommended next steps to management. At critical junctures, organize and participate in information exchanges with preclinical, clinical, or business development teams, providing necessary support.
7.Support platform operations: Oversee daily lab management for assigned areas, including maintenance of key instruments, reagent inventory management, and contribute to maintaining a safe and efficient laboratory environment.
8.Assist in team management: In line with company needs, participate in recruiting qualified new staff, and continuously mentor, train, and enhance the professional skills of new employees. Foster employee motivation and a sense of belonging and team cohesion. Support routine departmental management duties, including but not limited to lab management, safety, and departmental system development.
9.Lead the team in drafting and reviewing experimental reports, ensuring rigor, data accuracy, and logical clarity, and perform quality control on final outputs.
10.Complete other tasks assigned by supervisors.
1.Ph.D. in biology or a related field, with a strong background in basic research and demonstrated achievements. Solid hands-on experience in both in vitro and in vivo experiments during doctoral training. Possess rigorous scientific thinking and excellent experimental skills, with the ability to independently design and complete research projects. Prior experience as a CRO Study Director or Project Manager is preferred.
2.Proficient in common in vitro analytical and detection methods, with a clear understanding of the development and validation of in vitro assays.
3.Familiar with commonly used animal models of disease, including their advantages, limitations, translational relevance to human diseases, and specific characterization and detection methods for these models.
4.Strong sense of responsibility, proactive learning ability, and initiative, with the capability to thrive in a fast-paced, cross-functional team environment.
5.Good communication and coordination skills.
6.Strong team-oriented collaboration mindset.
7.Good written and verbal communication skills in both Chinese and English.
Biology scientist (in vitro)
Shanghai R&D1.Construction and Transfection Optimization of Complex Cell Models: Independently perform culture, subculture, cryopreservation, and recovery of various mammalian cell lines (e.g., suspension/adherent CHO, HEK293, hepatocytes, etc.). Lead the execution of transient or stable transfection of target genes using liposome-based reagents, electroporation, or viral transduction. Optimize transfection conditions across different cell lines, screen and establish stable cell lines expressing target proteins or containing desired gene edits, and ensure robust establishment and functional validation of cell models.
2.High-Throughput Screening (HTS) Cell-Based Assays: Design and execute HTS experiments using 96-/384-well plate formats. Operate automated equipment including high-content imagers, microplate readers, or flow cytometers to rapidly assess phenotypic readouts such as cell viability, reporter gene expression, or protein expression. Conduct large-scale data acquisition and analysis to support early-stage drug discovery and target validation efforts.
3.Precise Primer and Probe Design and Validation: Design qPCR primers and probes (compatible with SYBR Green or TaqMan chemistries) using software such as Primer-BLAST, SnapGene, or Oligo, based on target gene sequences or specific mutation sites. Independently validate primer specificity and amplification efficiency, establish standard curves, and ensure accuracy and reproducibility in subsequent gene expression quantification.
4.High-Quality qPCR Gene Expression Analysis: Extract high-quality total RNA (or DNA) from cell samples, perform reverse transcription and real-time quantitative PCR (qPCR) to measure target gene mRNA expression levels or gene editing efficiency. Strictly adhere to MIQE guidelines, analyze data using relative quantification methods (e.g., 2^(-ΔΔCt)), troubleshoot abnormal amplification or melting curves, and maintain detailed experimental records and comprehensive reports.
5.Data Analysis, Method Optimization, and Platform Maintenance: Integrate HTS and qPCR datasets, perform statistical analysis and data visualization using tools such as GraphPad Prism, Excel, or R, and generate complete research reports. Continuously optimize the entire workflow from cell transfection and screening to detection. Oversee routine maintenance of key instruments (e.g., real-time PCR systems, flow cytometers, multi-mode plate readers) and manage related consumables and reagents.
6.Additional Duties: Complete other tasks as assigned by supervisory personnel.
1.Education and Experience: Bachelor's degree in Cell/Molecular Biology, Immunology, Pharmacy, or other biology/medical-related fields, with at least 3 years of post-graduate work experience (the most recent position must include >1 year of hands-on cell culture work); OR a Master's degree (fresh graduates are acceptable provided that their research primarily focused on cell-based experiments). Prior experience in nucleic acid drug development is strongly preferred.
2.Technical Skills: Proficient in standard cell biology and biochemical laboratory techniques. Experience in cell-based assay development and/or authoring reports for IND filings is highly desirable.
3.Core Competencies: Demonstrated expertise in cell culture, transfection, RNA extraction, qPCR, Western blot, and ELISA. Experience with high-throughput screening (HTS) is required.
4.Software Proficiency: Skilled in Microsoft Office Suite; knowledge of or familiarity with scientific graphing and statistical analysis software such as GraphPad Prism and SPSS is preferred.
5.Soft Skills: High sense of responsibility, proactive and self-motivated work ethic, strong organizational and coordination abilities, excellent teamwork and scientific innovation mindset, and the capacity to perform effectively under pressure.
Principal Scientist(AD-SD)(Extrahepatic delivery)
Shanghai R&D1.Scientific Leadership & Strategy：Provide scientific leadership for extrahepatic oligonucleotide delivery programs, from early discovery through clinical candidate nomination；Define and drive delivery strategies targeting non-hepatic tissues (e.g., heart, muscle, CNS, or other peripheral tissues)；Establish best practices, screening cascades, and decision criteria for delivery optimization and PCC nomination.
2.Delivery Platform Development：Design, optimize, and evaluate delivery approaches including lipid conjugates, peptide/ligand conjugates, and antibody–oligonucleotide conjugates (AOCs)；Lead structure–activity relationship (SAR) studies to optimize conjugate chemistry, linker design, and tissue selectivity；Integrate PK, biodistribution, and PD data to guide compound design and translational strategy.
3.Preclinical Research & Data Interpretation：Oversee and interpret in vitro and in vivo studies (mouse and NHP) to assess delivery efficiency, tissue specificity, and safety；Critically analyze complex datasets and provide clear scientific recommendations to project teams and leadership；Identify risks related to delivery, safety, and manufacturability early and propose mitigation strategies.
4.Cross-Functional Collaboration：Collaborate closely with CMC, DMPK, toxicology, bioinformatics, and clinical teams to advance programs toward IND；Partner with external collaborators and CROs to execute specialized studies；Contribute to patents, scientific publications, and regulatory documentation；Present data and strategic recommendations to internal governance teams and external stakeholders.
1.PhD in Molecular Biology, Pharmacology, Chemistry, Bioengineering, or a related field with 3+ years of demonstrated leadership in drug discovery and extrahepatic delivery platform development in industry.
2.Deep expertise in oligonucleotide therapeutics (siRNA, ASO) and extrahepatic delivery strategies.
3.Strong understanding of delivery barriers, tissue targeting, PK/PD relationships, and translational considerations.
4.Proven track record of advancing discovery programs toward development candidates.
5.Demonstrated ability to lead complex, cross-functional projects in a fast-paced biotech environment.
6.Excellent problem-solving, communication, and scientific storytelling skills.
1.Experience with NHP studies and translational PK/PD modeling.
2.Experience contributing to IND-enabling activities or early clinical development.
3.Background in cardiovascular, neuromuscular, or other extrahepatic disease areas.
4.Prior experience with antibody–oligonucleotide conjugates, peptide-mediated delivery, or lipid conjugation technologies.
Principal Scientist (Histopathologist)
Shanghai R&D1.Serve as the histopathology subject-matter expert across discovery, lead optimization, and IND-enabling studies.
2.Define histopathology strategies to support target validation, delivery platform evaluation, and safety risk assessment.
3.Establish best practices for tissue collection, processing, staining, grading, and interpretation across organs (heart, muscle, liver, kidney, CNS, spleen, lung, etc.), as well as work in the lab to conduct histological staining.
4.Interpret histopathology data from rodent and NHP studies, including pharmacology and exploratory safety studies.
5.Integrate pathology findings with PK, tissue exposure, PD, and functional data to support mechanistic understanding.
6.Differentiate on-target, delivery-related, and off-target/toxicologic findings.
7.Provide clear scientific recommendations on dose selection, study design, and risk mitigation.
8.Work closely with CRO pathologists; review slides, reports, and peer-review pathology findings.
9.Ensure pathology data quality, consistency, and regulatory readiness.
10.Present pathology findings and integrated interpretations to senior leadership and project teams.
11.Contribute to publications, patents, and scientific communications where appropriate.
12.Mentor junior scientists and help build pathology capabilities within the organization.
1.PhD and/or DVM in Pathology, Veterinary Pathology, Toxicologic Pathology, or a related discipline.
2.5+ years of relevant experience in biotech/pharma or CRO environments, with demonstrated scientific leadership.
3.Strong expertise in rodent and NHP histopathology.
4.Proven ability to interpret pathology data in the context of drug mechanism, delivery, and PK/PD.
5.Excellent scientific judgment, communication, and cross-functional collaboration skills.
Preferred Qualifications:
1.Board certification (e.g., ACVP) or eligibility strongly preferred.
2.Experience supporting oligonucleotide or novel delivery platforms.
3.Experience with cardiovascular, skeletal muscle, kidney, and CNS pathology.
4.Prior involvement in IND-enabling toxicology studies and regulatory interactions.
Sr. Scientist I-III (Skeletal Muscle)
Shanghai R&D1.Utilize molecular, cellular, and biochemical techniques to identify and validate novel therapeutic targets for muscle and metabolic diseases.
2.Serve as the project lead and collaborate with cross-functional teams to advance discovery programs to IND stage.
3.Design and execute in vitro/in vivo studies for target validation and understanding the mechanisms.
4.Develop in vitro assays, including but not limited to WB, ELISA, qPCR, enzymatic assay, etc.
5.Analyze and interpret complex data sets and present findings to internal and external stakeholders.
6.Stay current with scientific literature and emerging technologies in the fields of skeletal muscle biology and metabolic disorders including obesity and type II diabetes.
7.Contribute to the preparation of scientific publications, patents, and regulatory documents.
8.Supervise and train associates or junior scientists.
9.Maintain accurate and detailed laboratory records and ensure compliance with company policies and regulatory requirements.
1.PhD in Physiology, Molecular Biology, Pharmacology, or a related field.
2.Strong background in skeletal muscle biology and knowledge/experience in drug development for metabolic diseases by targeting skeletal muscles.
3.Hands-on experience with preclinical models of skeletal muscle diseases and related functional tests.
4.Good understanding and experienced in various biophysical assays and cell-based assays such as but not limited to FACS, WB, qPCR, muscle cell culture and differentiation, etc.
5.Proficiency in data analysis and visualization tools.
6.Excellent problem-solving skills and the ability to work independently and as part of a team.
7.Strong written and verbal communication skills, with a track record of scientific publications and presentations.
8.Demonstrated ability to manage multiple projects and meet deadlines in a fast-paced environment.
1.Knowledge of drug discovery and development processes.
2.Familiarity with translational research and biomarker discovery.
3.Experience with RNA biology, oligonucleotide therapeutics (siRNA, ASO), and targeted delivery strategies.
Senior Biology Scientist I
Shanghai R&D1.New target due diligence, validation, and project initiation: including but not limited to investigating target biology mechanisms, the relationship between aberrant target activity and disease pathogenesis, current and potential treatment modalities and competitive landscape for diseases and specific indications, disease epidemiology, and market potential. Compile comprehensive due diligence reports and provide clear recommendations on whether to initiate a project. If critical information for the go/no-go decision is missing, clearly identify the gaps, develop actionable work plans to further validate the target through experiments, collect the missing key data, and provide a definitive recommendation on project initiation based on the findings.
2.Pipeline project execution: Work with company management to define overall project goals and milestone objectives, project team composition, and required internal and external resources. Develop detailed and executable work plans, including timelines for achieving each milestone. Fully communicate the specific work scope and timelines at each project stage to the project team, ensuring that all cross-functional teams clearly understand their tasks and priorities. Coordinate work across project teams, track project execution progress, promptly organize key project data, and arrange next steps or make timely course corrections based on results, while reporting to management with recommendations on future directions and priorities. At critical junctures, organize and participate in information exchange and communication with preclinical, clinical, or BD teams, providing necessary support.
3.Development of extrahepatic delivery platform technologies: Assist in the development and optimization of extrahepatic delivery platforms beyond the central nervous system. Specific responsibilities include investigating delivery targets for specific tissues, understanding the biological mechanisms of delivery targets, tracking and analyzing competitive programs, and discovering or screening tool compounds for validating delivery targets. Work with management to define overall work plans for delivery target validation and further development, team composition, and internal/external resource allocation. Collect and organize experimental data, generate reports for distribution to the project team and management, and provide recommendations for next steps. Timely resolve technical challenges encountered during the project; escalate to supervisors for guidance or additional resources as necessary to facilitate rapid resolution.
4.Exploration and development of new technologies and methods within the department: In line with the company's overall strategy and project needs, explore, develop, and refine key in vivo and in vitro analytical and detection methods. Establish standard operating procedures (SOPs) and train relevant personnel to ensure data consistency and method sustainability. Evaluate and progressively procure essential equipment for the biology laboratory, and organize the management, maintenance, and training for specialized instruments.
5.External collaborations: For specific project collaborations with potential partners, responsibilities include, in addition to those outlined in the pipeline project execution section above, communicating with partners to develop work plans, set timelines and budgets, track progress to ensure implementation as planned, and provide regular updates on project status and next steps. Promptly communicate and address issues encountered during collaborations, working with partners to identify solutions.
6.Support for other company project teams: As needed, coordinate departmental resources to assist other project teams in completing high-priority tasks.
7.CRO management: Participate in CRO evaluation, develop detailed work plans, work with the operations team to clarify contract scope and budgets, organize regular meetings to monitor CRO progress, and provide periodic updates to company management. If critical issues or difficulties arise during project execution, promptly communicate with management to seek guidance or additional resources for timely resolution, and provide specific recommendations for course correction when necessary.
8.Serve as a blinded team member in clinical trials: Participate in the organization and preliminary analysis of PK/PD and other bioanalytical data, ensuring data quality and procedural compliance while maintaining blinding integrity.
9.Complete other tasks assigned by the supervisor.
1.Ph.D. in Biology or a related field, with less than two years of work experience. Demonstrated strong foundational research background and track record of scientific achievements.
2.Proficiency in common in vivo and in vitro analytical and detection methods, with a clear understanding of the development and validation of in vitro assays.
3.Familiarity with commonly used animal models of human diseases, with an understanding of their respective advantages and limitations, translational relevance to human diseases, and the specific characterization and detection methods applicable to these models.
4.Strong willingness and ability for continuous self-learning.
5.Excellent cross-functional communication and coordination skills.
Biology Scientist (in vivo)
Shanghai R&D1.Drafting animal study reports for the in vivo biology department, and scanning/filing hard-copy reports.
2.Developing dilution protocols for test articles, preparing drug dilutions, and conducting concentration measurement, adjustment, and documentation.
3.Preparing materials required for in vivo biology department experiments, and aliquoting necessary reagents.
4.Aliquoting serum and plasma samples collected from animal studies.
5.Proactively identifying errors in experimental reports and reporting them to the supervisor.
6.Completing other tasks assigned by the supervisor.
1.Associate degree or above (fresh graduates welcome) in Veterinary Medicine, Animal Husbandry and Veterinary Science, Animal Science, Biology, or a related field.
2.Basic knowledge of routine experimental procedures in mice and rats.
3.Good communication and teamwork skills.
Biology Scientist I–III (Cytotoxicity)
Shanghai R&D1.Responsible for the experimental development and testing of small nucleic acid cytotoxicity.
2.Responsible for the experimental development and testing of small nucleic acid immunogenicity analysis.
3.Develop, optimize, and validate in vitro analytical methods, including but not limited to cell culture, transfection, flow cytometry analysis, gene editing and overexpression cell line construction, as well as molecular biology experiments such as RNA extraction, qPCR, Western blot, ELISA, and MSD.
4.Strictly adhere to standard operating procedures for relevant analytical methods; assist the team in optimizing assay conditions, and participate in the drafting of SOPs.
5.Report experimental results and complete experimental records and study reports.
6.Responsible for the routine maintenance, status monitoring, and basic cleaning management of key instruments (e.g., flow cytometers, qPCR systems, plate readers, MSD instruments, etc.).
7.Coordinate cross-departmental communication and project resource allocation; perform quality review and verification of test reports.
8.Complete other tasks assigned by supervisors.
1.Master's degree in Biology or a related field; exceptional bachelor's degree holders will also be considered; relevant work experience is preferred.
2.Must possess a solid foundation in mammalian cell culture; experience with cell transfection or electroporation is preferred; experience in isolating and culturing PBMC cells and performing immune factor detection is a plus.
3.Experience in ASO or siRNA in vitro screening is preferred.
4.Familiar with the development and optimization processes of various in vitro analytical methods; have a clear understanding of the principles and validation of high-throughput in vitro assays; experience in neurobiology R&D is preferred.
5.Hands-on experience with at least two of the following core laboratory techniques: qPCR, plate reader assays, flow cytometry, or ELISA/MSD.
6.Proficient in Microsoft Office suite; knowledge of or familiarity with scientific graphing and data analysis software such as GraphPad Prism is preferred.
7.Project management experience is a plus.
8.Strong sense of responsibility, proactive work attitude, excellent organizational and coordination skills, good team collaboration spirit, innovative thinking in scientific research, and the ability to work effectively under pressure.
Biology Scientist I–III (ASO)
Shanghai R&D1.Responsible for the development, optimization, and validation of routine in vitro analytical methods.
2.Develop and establish robust analytical methods for small nucleic acid drugs, utilizing technologies including but not limited to PCR, qPCR, and reporter gene assays.
3.Develop and optimize pharmacokinetic (PK) assay methods: establish and refine immunological methods for the quantitative detection of drug concentrations in biological matrices (e.g., plasma, serum, and tissues), primarily using ELISA and MSD platforms.
4.Provide key proof-of-concept data for early-stage discovery and screening programs by performing feasibility and validation experiments. Experimental procedures include but are not limited to cell culture, transfection, flow cytometry analysis, gene editing and overexpression cell line construction, as well as RNA extraction, qPCR, Western blot, ELISA, MSD, and HTRF.
5.Maintain thorough and accurate experimental records and document all experimental observations.
6.Summarize work results in a timely manner and submit experimental data and documentation as required.
7.Engage in cross-departmental communication to discuss experimental data and work plans.
8.Complete other tasks assigned by supervisors.
1.Master's degree in Biology or a related field, with at least 3 years of experience in a biopharmaceutical company or CRO.
2.Proficient in the development and optimization of various in vitro analytical methods, with a clear understanding of the principles and validation of high-throughput in vitro assays. Experience in small nucleic acid therapeutics and neurobiology R&D is highly preferred.
3.Ability to independently operate instruments including cell culture equipment, qPCR systems, flow cytometers, plate readers, and MSD platforms, as well as perform statistical analysis of experimental data.
4.Proficient in Microsoft Office suite; familiarity with or working knowledge of scientific graphing and data analysis software such as GraphPad Prism is preferred.
5.Strong sense of responsibility, proactive work attitude, excellent organizational and coordination skills, good team collaboration spirit, innovative thinking in scientific research, and the ability to work effectively under pressure.
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