Physician in Cardiology in heart failure and cardiomyopathy (AD-VP)
Shanghai Clinical Development1.Lead clinical development. Provide clinical as well as general medical expertise throughout developments, from clinical development plan, protocol development through study conduct, regulatory submission(s) and product launch.
2.Provide expert input to the clinical studies and provide oversight of protocol development, in collaboration with partner’s global teams (if applicable)
3.Responsible for protocols to identify region-specific operational issues for the territory. Where necessary, provide medical oversight of clinical project
4.Provide expert input to the clinical studies and provide oversight of protocol. Perform as medical monitor or oversight for CRO partners on medical queries and issues.
5.Provide medical expertise in interactions with regulatory agencies
6.Attend investigator meetings; deliver clinical presentations as needed
7.Oversight vendors as needed to ensure successful clinical studies for regulatory submission goal
8.Proactively identify key investigators in the region and cultivate long-term collaborations. Recruit and manage regional Clinical Advisory Board if needed
9. Establish and maintain appropriate collaborations and relationships with external scientific experts, thought leaders, and the general medical community
1.Medical Doctor degree or Master degree of relevant therapeutic area
2.At least 3-5 years of clinical development or pharmaceutical medical function experience（HCM/DCM）
3.Previous experiences in IND/NDA submission and interacting with regulatory authorities preferred
4.Good communication skills and presentation skills
5.Fluent English in written and verbal
Medical AD-VP (Neuro)
Shanghai Clinical Development1.Lead clinical development. Provide clinical as well as general medical expertise throughout developments, from clinical development plan, protocol development through study conduct, regulatory submission(s) and product launch.
2.Provide expert input to the clinical studies and provide oversight of protocol development, in collaboration with partner’s global teams (if applicable)
3.Responsible for protocols to identify region-specific operational issues for the territory. Where necessary, provide medical oversight of clinical project
4.Perform as medical monitor or oversight for CRO partners on medical queries and issues
5.Provide medical expertise in interactions with regulatory agencies
6.Attend investigator meetings; deliver clinical presentations as needed
7.Oversight vendors as needed to ensure successful clinical studies for regulatory submission goal
8.Proactively identify key investigators in the region and cultivate long-term collaborations. Recruit and manage regional Clinical Advisory Board if needed
9.Establish and maintain appropriate collaborations and relationships with external scientific experts, thought leaders, and the general medical community
1.Medical Doctor degree or Master degree of relevant therapeutic area
2.5+ years of clinical development or pharmaceutical medical function experience
3.Previous experiences in IND/NDA submission and interacting with regulatory authorities preferred
4.Good communication skills and presentation skills
5.Fluent English in written and verbal
Neuro-image Director AD-SD
Shanghai Clinical Development1.Proficient in advanced neuroimaging software (HERMES, PMOD, FSL, SPM) for multimodal analyses (fMRI, PET, DTI, MRS) to identify biomarkers of neurological disorders (e.g., Alzheimer’s, Parkinson’s), with expertise in lesion segmentation, functional assessment, metabolic quantification, and time-series modeling
2.Conduct qualitative and quantitative analyses of neuroimaging data, extract key information (such as regional brain volumes, metabolic levels, and functional connectivity), and perform research tasks including image registration and brain atlasconstruction
3.Assess the treatment effect by monitoring structural or functional changes in the brain before and after treatment through dynamic imaging
4.Integrate imaging data with genetic, behavioral, and clinical scale information to develop predictive models for disease progression and/or treatment effect assessment.
5.Assist in designing multicenter, prospective clinical trials to validate the imaging biomarkers as surrogate endpoints or efficacy assessment tools
6.Support the clinical development of neuroscience pipeline, and the optimization of data modeling or software tools.
7.Ensure the standardization of image data acquisition and processing procedures, participate in image quality review, and provide reliable data support for clinical trials or product development.
8.Collaborate with clinical medical teams and technical teams without medical backgrounds, providing relevant professional knowledge support to assist in clinical trials, preclinical research, or product analysis.
9.Undertake additional duties assigned by superiors.
1.Master’s degree or higher in Clinical Medicine, Neuroscience, Medical Imaging, Anatomy, Computer Science, or a closely related field with proficiency in programming (Python, R, Shell) and hands-on experience in image analysis
2.Minimum of 3 years of relevant experience, with expertise in integrating structural (T1/T2), functional (fMRI), diffusion (DTI), and metabolic (PET) imaging. Having working experience in neurodegeneration disease pipeline development such as Alzheimer’s disease (AD) , Parkinson’s disease (PD) and Huntington’s disease (HD) will be preferred.
3.Familiar with clinical trial processes especially clinical protocol & vendor selection, Good Clinical Practice (GCP), ICH guidelines, and related regulations
4.Proficient in commonly used office software, including Word, Excel, PowerPoint, and Outlook
5.Excellent English reading and writing skills, with strong proficiency in English communication
Medical Director (AD-VP) (EU)
Switzerland Clinical Development1.Global Clinical Development Strategy：Develop global clinical development strategies for Argo's pipeline assets and focus on the execution in EU；Define and adapt clinical development plan and pathways, including: Phase I–III trial strategy，Patient population selection，Endpoint strategy，Biomarker strategy，Regulatory pathway planning；Provide medical leadership throughout clinical development lifecycle；Inform Target Product Profile for relevant assets；Global Regulatory & Trial Leadership；Lead clinical interactions with EMA, MHRA, FDA, and other international regulatory authorities；Support IND, CTA, BLA/NDA/MAA preparation activities；Provide clinical input into regulatory briefing packages and submission documents.
2.Cross-functional Leadership:Partner closely with: Clinical Operations, Regulatory Affairs, Translational Medicine, Biometrics, Safety/PV, CMC, Commercial Strategy；Provide clinical leadership for global development teams and CRO partners including oversight
3.External Scientific Leadership：Build relationships with international KOLs, investigators, academic institutions & patient advocacy groups
Represent Argo at scientific conferences and advisory boards，Support publications, abstracts, and medical communications.
4.Organizational Development:Grow Argo's global clinical development organization;Manage & Mentor clinical development professionals and build international capabilities;Maintain line of sight on internal developments across related disease areas.
1.MD, MD/PhD, or equivalent medical/scientific qualification preferred
2.10+ years of clinical development, including within biothech/pharma
3.International experience
4.Significant experience leading global clinical trials
5.Strong understanding of FDA and EMA clinical development requirements
6.Proven experience advancing innovative therapies from early clinical stages toward registration
7.Previous experiences in IND/NDA submission and interacting with regulatory authorities (EMA, MHRA, FDA)
8.Experience with RNA therapeutics, siRNA, oligonucleotide therapies, gene therapy, or other advanced modalities strongly preferred
9.xperience in cardiovascular, metabolic disease, rare disease, hematology, CNS, or immunology preferred
10.Strong leadership experience managing global cross-functional teams
Clinical Development VP
Shanghai Clinical Development1.Support CMO to develop and execute the company's strategic goals and
objectives.
2.Lead team to support clinical development including pipeline and competitor intelligence analysis, TPP & clinical development plan, study protocol development, study conduct, regulatory submission, product launch and post-market medical affairs support.
3.Build up clinical research physician team including recruitment, hiring, training,coaching and performance evaluation to ensure a competent and motivated workforce
4.Manage the team's budget and resources, optimizing efficiency and cost-effectiveness
5.Ensure compliance with all regulatory requirements, including GCP quality assurance system and programs
6.Medical oversight on CRO as needed to ensure successful clinical studies for regulatory submission goal
7.Foster a culture of continuous quality improvement, monitoring key performance indicators and implementing initiatives to optimise processes
8.Lead and encourage collaboration, communication and knowledge sharing among cross-function team
9.Establish and maintain appropriate communication and collaborations with external scientific experts, thought leaders, the general medical community and health authorities.
10.Other tasks assigned by senior management.
1.Medical Doctor degree or master degree in clinical medicine
2.Minimum of 7~10 years of clinical development or pharmaceutical medical function experience, with 3~5 years in a medical leadership role. Having experience in both of MNC and biotech is preferred. Have experience in early phase clinical development (Ph1-Ph2a) and later phase (Ph2b-3) clinical development is preferred.
3.Experience in IND/NDA submission and interacting with regulatory authorities.Experience with FDA or EMEA is preferred
4.Strong leadership with the ability to inspire and engage others to achieve common goals.
5.Extensive knowledge of clinical development related laws & regulations, quality standard and best practice
6.Strong strategic thinking, problem-solving skills, driving innovation and process improvement.
7.Good communication skills and presentation skills
8.Fluent English in written and verbal
9.Commitment to continuous learning and self-development
Global CMO
USA Clinical Development1.Global Clinical Development Strategy: Develop and execute the global clinical development strategy for the company’s product pipeline, ensuring alignment with corporate goals and regulatory requirements.Lead the design and execution of clinical trials across various phases (I-III), with a focus on cardiovascular diseases (i.e, heart failure, cardiomyopathy, anticoagulation), CNS diseases (Huntington Disease, Alzheimer's Disease, Parkinson Disease, neuromuscular disease).Provide strategic input into business development activities, including due diligence for potential in-licensing or acquisition opportunities.
2.Regulatory and Compliance Leadership:Oversee the preparation and submission of regulatory documents, including INDs, NDAs, BLAs, and other relevant filings to ensure timely approval and commercialization of our products.Ensure compliance with global regulatory guidelines and industry best practices in clinical research and development.
3.Medical Affairs and Stakeholder Engagement:Serve as the primary medical spokesperson for the company, representing the clinical development programs to regulatory agencies, key opinion leaders, investors, and other external stakeholders.Provide strategic leadership for medical affairs, including medical communications, scientific publications, and engagement with key opinion leaders.Collaborate with cross-functional teams to drive the overall medical strategy and ensure seamless integration with commercial objectives.
4.External Partnerships and Collaborations:Identify and establish relationships with key opinion leaders, clinical investigators, and academic institutions to support clinical trial execution and scientific exchange.Represent the company at industry conferences, scientific meetings, and regulatory forums.
5.Team Leadership and Development:Build and lead a high-performing clinical development team, fostering a culture of innovation, collaboration, and scientific rigor.Mentor and develop talent within the organization to support long-term growth and success.
1.MD or equivalent degree in a relevant medical field. Additional qualifications in an MBA are highly desirable.
2.Minimum of 15 years of experience in the pharmaceutical or biotechnology industry, with a strong track record in clinical development and medical affairs. Previous experience in Oligo is a plus.
3.Proven experience in leading global late-stage clinical programs, particularly in non-oncology therapeutic focusing on cardiovascular diseases (Heart failure, cardiomyopathy, anticoagulation), , CNS diseases (HD, AD, PD, neuromuscular disease).
4.Strong scientific acumen and deep understanding and extensive experience in designing and executing clinical trials, including Phase 1-3 studies, and a deep understanding of regulatory requirements (FDA, EMA, CDE etc.), Previous experience in Phase 4 studies is a plus.
5.Strategic thinker with a strong business acumen and the ability to contribute to the overall corporate strategy.
6.Excellent communication and presentation skills, with the ability to effectively communicate complex scientific and clinical information to diverse audiences.
7.Demonstrated ability to build and lead high-performing teams in a fast-paced, dynamic environment.
8.A strong sense of urgency, deep commitment, and an intimate conviction as it relates to Argo’s Purpose and Mission.
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